MMP9-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-MMP9(Cat#: CyOV-0287XY)
DatasheetThis product is a MMP9 expressing oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
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| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔICP10PK) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP10PK |
| Promoter | CMV |
| Transgene | MMP9 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Matrix metallopeptidase 9 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Neurodegenerative diseases |
Transgene | |
|---|---|
| Alternative Names | MMP9, GELB, CLG4B, MMP-9, MANDP2, matrix metallopeptidase 9 |
| Gene ID | 4318 |
Information | |
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| Introduction | Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. |
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