IL-18-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), SV40-IL-18(Cat#: CyOV-0376XY)
DatasheetThis product is a IL-18 expressing oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔICP10PK) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP10PK |
| Promoter | SV40 |
| Transgene | IL-18 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 18 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Neurodegenerative diseases |
Transgene | |
|---|---|
| Alternative Names | IGIF, IL-18, IL18, IL-1g, IL1F4, interleukin 18 |
| Gene ID | 3606 |
Information | |
|---|---|
| Introduction | Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for IL-18-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), SV40-IL-18 (CyOV-0376XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), CMV-IL-4 (CAT#: CyOV-0070XY)
- hTNFα-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-hTNFα (CAT#: CyOV-0019XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), CMV-lacZ (CAT#: RepOV-0022XY)
- ING4-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), CMV-ING4 (CAT#: CyOV-0062XY)
- CCL2-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-CCL2 (CAT#: CyOV-0282XY)
- mCherry-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), IE4/5-mCherry (CAT#: RepOV-0150XY)
- hTNFα-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), IE4/5-hTNFα (CAT#: CyOV-0355XY)
- HSP70-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), CMV-HSP70 (CAT#: CyOV-0298XY)
PRODUCTS
Online Inquiry