CCL17-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), CMV-CCL17(Cat#: CyOV-0295XY)
DatasheetThis product is a CCL17 expressing oncolytic herpes simplex virus, which is based on HSV-2 with RL deleted. The deletion lies entirely within the sequences deleted in JH2604 in which only 850 bp are removed from the RL. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔRL) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔRL |
| Promoter | CMV |
| Transgene | CCL17 |
| Type of Transgene | Cytokine |
| Related Target/Protein | C-C motif chemokine ligand 17 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | CCL17, A-152E5.3, ABCD-2, SCYA17, TARC, C-C motif chemokine ligand 17 |
| Gene ID | 6361 |
Information | |
|---|---|
| Introduction | Chemokine (C-C motif) ligand 17 (CCL17) (also known as TARC) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1. |
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