hTNFα-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), CMV-hTNFα(Cat#: CyOV-0299XY)
DatasheetThis product is a hTNFα expressing oncolytic herpes simplex virus, which is based on HSV-2 with RL deleted. The deletion lies entirely within the sequences deleted in JH2604 in which only 850 bp are removed from the RL. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔRL) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔRL |
| Promoter | CMV |
| Transgene | hTNFα |
| Type of Transgene | Cytokine |
| Related Target/Protein | Tumor necrosis factor alpha |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | hTNFα, DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF, tumor necrosis factor |
| Gene ID | 7124 |
Information | |
|---|---|
| Introduction | Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for hTNFα-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), CMV-hTNFα (CyOV-0299XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- EGFP-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), CMV-EGFP (CAT#: RepOV-0014XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-lacZ (CAT#: RepOV-0136XY)
- hTNFα-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), IE4/5-hTNFα (CAT#: CyOV-0145XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-lacZ (CAT#: RepOV-0010XY)
- IL-12-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), IE4/5-IL-12 (CAT#: CyOV-0360XY)
- EGFP-encoding Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), IE4/5-EGFP (CAT#: RepOV-0086XY)
- mCherry-encoding Oncolytic Herpes Simplex Virus 2 (ΔRL), hTERT-mCherry (CAT#: RepOV-0144XY)
- IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-IL-4 (CAT#: CyOV-0028XY)
PRODUCTS
Online Inquiry