4-1BBL-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3L), p11k-(4-1BBL)(Cat#: CyOV-0151WQ)

This product is a 4-1BBL encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L and K3L double deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Protein K3 acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff.The double deletion of E3L and K3L with oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR (ΔE3L,ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L,ΔK3L
Promoter p11k
Transgene 4-1BBL
Type of Transgene Cytokine
Related Target/Protein TNF superfamily member 9
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Lung Tumor, HCC

Transgene

Alternative Names CD137L; TNLG5A; 4-1BB-L
Gene ID 8744
UniProt ID P41273

Information

Introduction The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

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