GM-CSF-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3L), p11k-(GMCSF)(Cat#: CyOV-0154WQ)

This product is a GMCSF encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L and K3L double deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Protein K3 acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff.The double deletion of E3L and K3L with oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR (ΔE3L,ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L,ΔK3L
Promoter p11k
Transgene GM-CSF
Type of Transgene Cytokine
Related Target/Protein Granulocyte-macrophage colony-stimulating factor
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Melanoma, Breast Cancer

Transgene

Alternative Names CSF2; GMCSF
Gene ID 100137216
UniProt ID P04141

Information

Introduction Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

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