Cytokine-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3L), pSL-(CXCL10) (CyOV-0212WQ)

This product is a CXCL10 encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L and K3L double deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Protein K3 acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff.The double deletion of E3L and K3L with oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR (ΔE3L,ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L,ΔK3L
Promoter pSL
Transgene CXCL10
Type of Transgene Cytokine
Related Target/Protein C-X-C motif chemokine ligand 10
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Mammary tumor
Transgene
Alternative Names C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
Gene ID 3627
Information
Introduction This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression.
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