IL-21-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(IL-21)(Cat#: CyOV-0041WQ)

This product is a IL-21 expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted. IL-21 has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. The deletion of E3L and IL-21 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter p11k
Transgene IL-21
Type of Transgene Cytokine
Related Target/Protein Interleukin 21
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor

Transgene

Alternative Names Za11; IL-21; CVID11
Gene ID 59067
UniProt ID Q9HBE4

Information

Introduction This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Customer Reviews and Q&As

There are currently no customer reviews or questions for IL-21-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(IL-21) (CyOV-0041WQ). Click the button below to contact us or submit your feedback about this product.

All products and services are for Research Use Only. Not For Clinical Use.

Other products

PRODUCTS

Online Inquiry