IL-2-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(IL-2)(Cat#: CyOV-0037WQ)

This product is a IL-2 expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. The deletion of E3L and IL-2 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter p7.5k
Transgene IL-2
Type of Transgene Cytokine
Related Target/Protein Interleukin 2
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Colon cancer

Transgene

Alternative Names IL-2; TCGF; lymphokine
Gene ID 3558
UniProt ID P60568

Information

Introduction The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Customer Reviews and Q&As

There are currently no customer reviews or questions for IL-2-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(IL-2) (CyOV-0037WQ). Click the button below to contact us or submit your feedback about this product.

All products and services are for Research Use Only. Not For Clinical Use.

Other products

PRODUCTS

Online Inquiry