TNF-α-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(TNF-α)(Cat#: CyOV-0072WQ)

This product is a TNF expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted. The TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. The deletion of E3L and TNF expressing could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter p7.5k
Transgene TNF-α
Type of Transgene Cytokine
Related Target/Protein Tumor necrosis factor alpha
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Colon cancer

Transgene

Alternative Names DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene ID 7124
UniProt ID P01375

Information

Introduction This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

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