hEPO-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSL-hEPO(Cat#: CyOV-0025WQ)

This product is a EPO encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The encoded protein binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter pSL
Transgene hEPO
Type of Transgene Cytokine
Related Target/Protein Human erythropoietin
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor

Transgene

Alternative Names EP; DBAL; ECYT5; MVCD2
Gene ID 2056
UniProt ID P01588

Information

Introduction This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.

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