Cytokine-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p7.5k-(IL-12) (CyOV-0107WQ)

This product is a IL12 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. The deletion of K3L and IL-12 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter p7.5k
Transgene IL-12
Type of Transgene Cytokine
Related Target/Protein Interleukin 12
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor
Transgene
Alternative Names CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
Gene ID 3593
Information
Introduction This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
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