IL-6-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p7.5k-(IL-6)(Cat#: CyOV-0127WQ)

This product is a IL6 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL6 acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. The deletion of K3L and IL6 expressing could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter p7.5k
Transgene IL-6
Type of Transgene Cytokine
Related Target/Protein Interleukin 6
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Lung carcinoma

Transgene

Alternative Names CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Gene ID 3569
UniProt ID P05231

Information

Introduction This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.

Customer Reviews and Q&As

There are currently no customer reviews or questions for IL-6-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p7.5k-(IL-6) (CyOV-0127WQ). Click the button below to contact us or submit your feedback about this product.

All products and services are for Research Use Only. Not For Clinical Use.

Other products

PRODUCTS

Online Inquiry