IL-7-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-(IL-7)(Cat#: CyOV-0134WQ)

This product is a IL7 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7 is also important for B and T cell development. The deletion of K3L and IL6 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSE/L
Transgene IL-7
Type of Transgene Cytokine
Related Target/Protein Interleukin 7
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Lung carcinoma

Transgene

Alternative Names IL-7; IL7
Gene ID 3574
UniProt ID P13232

Information

Introduction The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.

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