Cytokine-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-(TNF-α) (CyOV-0149WQ)

This product is a TNF expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. The TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. The deletion of K3L and TNF expressing could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSE/L
Transgene TNF-α
Type of Transgene Cytokine
Related Target/Protein Tumor necrosis factor alpha
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Colon cancer
Transgene
Alternative Names DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene ID 7124
Information
Introduction This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
All services and products are for lab research only, not for any clinical use.

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