Cytokine-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSL-(IL-2) (CyOV-0115WQ)

This product is a IL-2 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. The deletion of K3L and IL-2 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSL
Transgene IL-2
Type of Transgene Cytokine
Related Target/Protein Interleukin 2
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Colon cancer
Transgene
Alternative Names IL-2; TCGF; lymphokine
Gene ID 3558
Information
Introduction The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
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