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Oncolytic Viruses in Glioblastoma Treatment

Introduction of Glioblastoma

Glioblastoma is a type of brain cancer and it is usually very aggressive. It’s the most common type of malignant brain tumor among adults. The symptoms of glioblastoma include constant headaches, seizures, vomiting, trouble thinking, changes in mood or personality, double or blurred vision, trouble speaking. Glioblastoma is associated with poor prognosis and the mean survival time is 15 months after diagnosis. The diagnosis by magnetic resonance imaging (MRI) or computed tomography (CT) is always depending on patients’ symptoms. The current standard of treatment includes surgery, radiation, and chemotherapy using temozolomide. No targeted antibodies or drugs have been demonstrated to be more efficient than temozolomide. According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18-20 months for adult patients with newly diagnosed glioblastoma. A high rate of failures in clinical trials and a lack of effective chemotherapy have driven scientists to develop distinct therapeutic approaches, including immunotherapy, chimeric antigen receptor (CAR) T-cell therapy and oncolytic virotherapy.

Oncolytic Viruses in Glioblastoma Treatment

Oncolytic Virus for Glioblastoma Treatment

Different oncolytic viruses have been tested in glioblastoma and proved feasibility and safety. Here present several phase I/II trials in recurrent glioma patients and demonstrated remarkable efficacy in subsets of patients.

Reference

  1. Stepanenko, A.A.; Chekhonin, V.P. Recent advances in oncolytic virotherapy and immunotherapy for glioblastoma: a glimmer of hope in the search for an effective therapy? Cancers. 2018, 10(12):492.

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