lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP27), CMV-lacZ(Cat#: RepOV-0004XY)
DatasheetThis product is a lacZ encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system when combined with other oncolytic-rendered modifications. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔICP27) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP27 |
| Promoter | CMV |
| Transgene | lacZ |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Beta-galactosidase |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | lacZ, b0344, ECK0341, beta-galactosidase |
| Gene ID | 945006 |
| UniProt ID | P00722 |
Information | |
|---|---|
| Introduction | The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP27), CMV-lacZ (RepOV-0004XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- IL-15-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), CMV-IL-15 (CAT#: CyOV-0305XY)
- HSP70-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), SV40-HSP70 (CAT#: CyOV-0368XY)
- CCL17-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), IE4/5-CCL17 (CAT#: CyOV-0155XY)
- vasculostatin-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-vasculostatin (CAT#: CyOV-0288XY)
- CCL17-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-CCL17 (CAT#: CyOV-0015XY)
- IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), IE4/5-IL-4 (CAT#: CyOV-0154XY)
- IL-18-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), CMV-IL-18 (CAT#: CyOV-0012XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-lacZ (CAT#: RepOV-0136XY)
PRODUCTS
Online Inquiry