lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-lacZ(Cat#: RepOV-0010XY)

This product is a lacZ encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant cellular enzyme encoded by the UL2 gene for removing uracil generated by hydrolytic deamination of cytosine or misincorporation of dUTP. The deletion of UDG may have contributed to lower rates of DNA repair during the passage or selection conditions. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.

Specifications

Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 1
Backbone HSV-1 (ΔICP34.5, ΔUNG)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP34.5, ΔUNG
Promoter CMV
Transgene lacZ
Type of Transgene Reporter gene
Related Target/Protein Beta-galactosidase
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Brain cancer

Transgene

Alternative Names lacZ, b0344, ECK0341, beta-galactosidase
Gene ID 945006
UniProt ID P00722

Information

Introduction The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose.

Customer Reviews and Q&As

There are currently no customer reviews or questions for lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), CMV-lacZ (RepOV-0010XY). Click the button below to contact us or submit your feedback about this product.

All products and services are for Research Use Only. Not For Clinical Use.

Other products

PRODUCTS

Online Inquiry