lacZ-encoding Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-(lacZ)(Cat#: RepOV-0052WQ)

This product is a lacZ encoding oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSE/L
Transgene lacZ
Type of Transgene Reporter gene
Related Target/Protein Beta-galactosidase
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine

Transgene

Alternative Names lacZ, b0344, ECK0341, beta-galactosidase
Gene ID 945006
UniProt ID P00722

Information

Introduction The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose.

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