Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsOtopetrin (OTOP) family is a group of multi-transmembrane domain proteins. Due to their role in the formation of otoconia and otoliths ("oto" means ear and "petros" means stone) in the inner ear, they are named as otopetrin. The member OTOP1 contains 12 transmembrane domains clustered into three conserved “Otopetrin Domains” (OD-1 to OD-III). Initially, studies revealed that OTOPs are the calcium transport proteins that regulate calcium homeostasis and influx of calcium in response to extracellular ATP. While following studies showed that OTOPs can be also regarded as the proton-selective ion channels. OTOP family as a regulator of biosynthesis of otoconia is involved in the normal processing of information regarding spatial orientation and acceleration. However, the mechanism of mediation otoconia formation by OTOP family is not clear. But it was reported that OTOP1 may regulate the calcium concentrations of the sensory epithelium and/or the globular substance vesicles secreted from the epithelium.
Here shows part of OTOP family in humans including OTOP1, OTOP2, and OTOP3, encoded by OTOP1, OTOP2, and OTOP3 genes. OTOPs in vertebrate possess the conserved genes and protein structures. Moreover, OTOP2 and OTOP3 regulate the calcium concentrations in a similar manner to OTOP2, suggesting a possible functional overlap between OTOPs.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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