Introduction of P2RX5
P2X purinoceptor 5 (P2RX5) is a membrane protein encoded by human P2RX5 gene, which is mapped to chromosome 17p13.2. P2RX5 belongs to the family of ATP-gated P2X receptor cation channel proteins and it acts as a sensor for the extracellular adenosine triphosphate (ATP). Upon ATP binding, P2RX5 can be exclusively activated to mediate calcium flux, induce large pore formation, and form signaling complexes with interacting proteins and membrane lipids. P2RX5 is expressed by a wide range of mammalian cells including neurons and glial cells in the central (CNS) and peripheral (PNS) nervous systems, muscle cells, epithelial cells, endothelial cells, endocrine cells, bone cells, and immune cells.
|Basic Information of P2RX5|
|Protein Name||Adhesion G-protein coupled receptor G2|
|Aliases||P2X5, P2X5R, purinergic receptor P2X 5|
|Organism||Homo sapiens (Human)|
Function of P2RX5 Membrane Protein
P2RX5 functions as a ligand-gated ion channel to regulate the selective permeability to cations, which is essential for various cellular functions, including proliferation and apoptosis, especially in bone remodeling and bone homeostasis. Additionally, P2RX5 is involved in the activation of the inflammasome, in the optimal inflammasome-induced IL-1β production by osteoclasts, and in osteoclast maturation and hyper-multinucleation. P2RX5 deficiency has been found to inhibit local osteoclast differentiation and activation, suggesting that P2RX5 may a potential therapeutic target in the context of periodontal disease and other selectively inhibiting inflammatory bone loss. Besides, there are many biological processes involving P2RX5, such as blood coagulation, nervous system development, regulation of calcium ion transport into the cytosol, regulation of calcium-mediated signaling, etc. P2RX5 is associated with Cystinosis disease.
Fig.1 A simple schematic representation of a ligand-gated ion channel.
Application of P2RX5 Membrane Protein in Literature
This article demonstrates that P2RX5 is indispensable for IL-1β production by osteoclasts and inflammasome activation mediated by ATP and that P2X5-deficient maturation in osteoclast is rescued in vitro by addition of exogenous IL-1β.
This article demonstrates that all P2Y receptor subtypes and the purinoceptors P2X3, P2X4, P2X5, and P2X7 can be detected in human dental pulp cells.
This article suggests that P2RX2 and P2RX5 may play a role in mediating bladder hyperesthesia in interstitial cells of Caja in the female overactive bladder.
This article confirms that the P2RX5 expression level is different in different syndrome groups at different ambient temperatures.
This article indicates a functional role of the human P2RX5 truncation variant in T cell activation and immunoregulation.
P2RX5 Preparation Options
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