Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y1 |
| Gene Name | P2RY1 |
| Uniprot | P47900 (Human); P49650 (Mouse) |
| Synonym | P2Y1; SARCC; ADP receptor; ATP receptor; P2 purinoceptor subtype Y1; platelet ADP receptor; purinergic receptor P2Y, G-protein coupled, 1; suppressing androgen receptor in renal cell carcinoma |
| Background | P2RY1, also known as purinergic receptor P2Y1, suppressing androgen receptor in renal cell carcinoma, P2 Purinoceptor Subtype Y1, platelet ADP receptor, SARCC, or purinergic receptor P2Y, is an about 42 kDa protein and constituted by 373 amino acids. In humans, it is encoded by the P2RY1 gene mapping at the chromosome 3q25.2. The encoded protein P2RY1 is a member of purinergic G-protein coupled receptor (GPCR) family, which has a number of receptor subtypes with diverse pharmacological selectivity, which overlaps in some cases, for many adenosine and uridine nucleotides. P2RY1 is expressed in almost all human tissues where it exerts numerous biological functions based on its G-protein coupling. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX83 | NativeExtract™ Human P2RY1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3489K | MemDX™ Membrane Protein Human P2RY1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0990X | MemDX™ Membrane Protein Human P2RY1 (Purinergic receptor P2Y1) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
Ali***ir: Highly recommended for membrane protein research.
12/Mar/2023
Ca***us: Custom P2RY1 service delivered truncated variants with intact extracellular domains in 6 weeks.
18/Oct/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Adenovirus-Mediated P2RY1 Overexpression in Cardiovascular Disease
Creative Biolabs offers adenovirus-mediated P2RY1 overexpression services. Adenoviral vectors encoding the P2RY1 gene have demonstrated efficacy in restoring purinergic signaling in ischemic heart models. By delivering functional P2RY1 to cardiomyocytes, this approach enhances ATP-mediated vasodilation and mitigates myocardial fibrosis. Creative Biolabs' viral vector engineering platform optimizes tropism and payload capacity, enabling precise targeting of cardiac tissues.
Knockdown for Oncological Applications
Creative Biolabs offers knockdown services. Silencing of P2RY1 in tumor microenvironments disrupts adenosine-driven immunosuppression, enhancing T-cell infiltration in preclinical studies. For instance, RNA-guided P2RY1 knockout in glioblastoma models reduced extracellular adenosine levels by 70%, potentiating checkpoint inhibitor efficacy. Creative Biolabs provides end-to-end design and validation services to accelerate such therapeutic pipelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY1 cell therapy. Please for more services.
CAR-T Cells Engineered with P2RY1 Modulatory Circuits
Creative Biolabs offers CAR-T cells engineered with P2RY1 modulatory circuits development services. Chimeric antigen receptor (CAR)-T cells incorporating P2RY1-responsive promoters demonstrate context-dependent activation in solid tumors. These circuits suppress adenosine-mediated exhaustion by downregulating P2RY1 signaling upon antigen engagement, prolonging antitumor activity. Creative Biolabs' immunofluorescence-based functional assays rigorously validate such dynamic cellular behaviors.
MSC-Secreted P2RY1 Antagonists for Inflammatory Disorders
Creative Biolabs offers MSC-secreted P2RY1 antagonists development services for inflammatory disorders. Mesenchymal stem cells (MSCs) engineered to secrete P2RY1-specific antibodies locally inhibit pro-inflammatory ATP signaling in rheumatoid arthritis synovia. In murine models, this strategy reduced joint swelling by 60% compared to controls. Creative Biolabs' gene expression profiling services ensure optimal transgene expression and safety in modified cell lines.
Creative Biolabs' multidisciplinary expertise—from viral vector design to validation and cell therapy optimization—positions us as your ideal partner in P2RY1-focused drug development. to discuss tailored strategies for your preclinical or clinical programs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
