Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y11 |
| Gene Name | P2RY11 |
| Uniprot | Q96G91 (Human) |
| Synonym | P2Y11; P2Y purinoceptor 11; purinergic receptor P2Y, G-protein coupled, 11 |
| Background | P2RY11, also known as purinergic receptor P2Y11, purinergic receptor P2Y, is a 40.3 kDa protein and a member of the family of G-protein coupled receptors (GPCRs). It consists of 374 amino acids and is determined to contain 2 exons. In humans, it is encoded by the gene P2RY11 located at the chromosome 19p13.2, where it is adjacent to the SSF1 gene. This intergenic splicing between them is a rare phenomenon in normal mammalian that probably has evolutionary implications. The human P2RY11 shares 33% identical to the human P2RY1 (its closest homolog) and is activated by adenine, however not the uridine nucleotide, to accelerate the pertussis toxin-insensitive phosphoinositide breakdown as well as cyclic AMP formation. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX77 | NativeExtract™ Human P2RY11 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3490K | MemDX™ Membrane Protein Human P2RY11 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0992X | MemDX™ Membrane Protein Human P2RY11 (Purinergic receptor P2Y11) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
A***y: Their custom P2RY11 service delivered N-terminal His-tagged constructs in 4 weeks.
09/Jul/2023
Cy***ss: Technical support ensured optimal buffer compatibility.
17/Jan/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Editing for Receptor Overexpression
Creative Biolabs offers gene editing services. Knock-in strategies enable precise integration of P2RY11 coding sequences into genomic safe harbor sites, enhancing receptor expression in hypoactive disease models. Creative Biolabs' optimized RNA design pipelines ensure minimal off-target effects while restoring purinergic signaling in neurodegenerative and immunodeficient conditions. This approach is particularly promising for disorders characterized by under-expression of P2RY11.
AAV-Delivered P2RY11 Agonist Constructs
Creative Biolabs offers AAV-delivered P2RY11 agonist constructs services. Recombinant adeno-associated virus (AAV) vectors engineered with tissue-specific promoters can selectively deliver constitutively active P2RY11 variants to diseased microenvironments. Creative Biolabs' proprietary AAV capsid libraries facilitate efficient transduction of immune cells or neuronal populations, demonstrating in vivo efficacy in preclinical models of neuroinflammation and metabolic dysregulation.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY11 cell therapy. Please for more services.
Engineered T-Cells with P2RY11 Signaling Modulators
Creative Biolabs offers development services for engineered T-Cells with P2RY11 signaling modulators. Chimeric antigen receptor (CAR) T-cells incorporating P2RY11-coupled intracellular domains show enhanced tumor infiltration in P2RY11-overexpressing solid malignancies. Creative Biolabs' lentiviral transduction platforms enable stable integration of these synthetic circuits, which co-opt endogenous purinergic signals to amplify anti-tumor cytotoxicity while mitigating cytokine release syndrome risks.
Stem Cell-Derived P2RY11+ Regulatory Networks
Creative Biolabs offers stem cell-derived P2RY11+ regulatory networks development services. Induced pluripotent stem cells (iPSCs) differentiated into P2RY11-enriched glial or dendritic lineages exhibit potent immunomodulatory activity in graft-versus-host disease models. Creative Biolabs' differentiation protocols ensure batch-to-batch consistency, leveraging small-molecule agonists to fine-tune receptor density during progenitor cell maturation.
Creative Biolabs' cross-disciplinary teams offer end-to-end support for P2RY11 therapeutic development, from target validation to IND-enabling studies. to schedule a technical consultation to explore:
- Customized vector design for tissue-specific P2RY11 modulation
- Functional validation of receptor signaling in disease-relevant models
- Scalable manufacturing solutions for gene-edited cell products
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
