Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y13 |
| Gene Name | P2RY13 |
| Uniprot | Q9BPV8 (Human); Q9D8I2 (Mouse) |
| Synonym | GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77; P2Y purinoceptor 13; G protein-coupled receptor 86; G-protein coupled receptor 94; purinergic receptor P2Y, G-protein coupled, 13 |
| Background | P2RY13, also known as purinergic receptor P2Y13, purinergic receptor P2Y, GPR86, GPR94, FKSG77, GPCR1, or SP174, is an approximately 41 kDa G protein-coupled receptor (GPCR) which is composed of 354 amino acids. GPCR plays a role in cell communication and is characterized by an intracellular C terminus, seven transmembrane regions, and an extracellular N terminus. P2RY13 is a receptor for ADP and in humans, encoded by the P2RY13 gene mapping at the chromosome 3q25.1. It is known to be activated by ADP and probably plays a role in the hematopoiesis and immune system. This receptor is strongly expressed in the spleen and adult brain, while at lower levels in placenta, liver, lung, thymus, uterus, stomach, testis, spinal cord, small intestine, fetal brain, and adrenal gland. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX75 | NativeExtract™ Human P2RY13 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3434K | MemDX™ Membrane Protein Human P2RY13 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0993X | MemDX™ Membrane Protein Human P2RY13 (Purinergic receptor P2Y13) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
S***on: Fast turnaround despite complex purification requirements.
06/Jul/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Editing for P2RY13 Functional Modulation
Creative Biolabs offers gene editing services for P2RY13 functional modulation. Precision genome editing systems enable the direct modification of P2RY13 to enhance or suppress its activity in disease-relevant cell populations. For instance, in metabolic disorders linked to aberrant purinergic signaling, knock-in strategies introducing gain-of-function mutations into the P2RY13 locus have demonstrated efficacy in restoring adenosine-mediated cytoprotective pathways. Creative Biolabs' optimized screening platforms provide end-to-end solutions for identifying and validating guide RNA sequences with <1% off-target rates, ensuring reliable therapeutic candidate development.
Adeno-Associated Virus (AAV)-Driven P2RY13 Overexpression in Neurodegenerative Models
Creative Biolabs offers AAV-driven P2RY13 overexpression services. AAV serotypes engineered for cell-specific tropism, such as AAV9 derivatives targeting microglial cells, deliver P2RY13 expression cassettes to modulate neuroinflammation in Alzheimer's models. Preclinical data reveal that sustained receptor overexpression reduces amyloid-β-induced cytotoxicity by 40% through enhanced phagocytic clearance mechanisms. Creative Biolabs' proprietary AAV capsid libraries enable the rapid identification of vectors with >90% transfection efficiency in myeloid-lineage cells, accelerating translational pipelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY13 cell therapy. Please for more services.
Engineered T Cells with P2RY13-Driven Metabolic Reprogramming
Creative Biolabs offers development services of engineered T cells with P2RY13-driven metabolic reprogramming. Chimeric antigen receptor (CAR) T cells incorporating P2RY13 as a co-stimulatory module exhibit enhanced antitumor persistence in solid malignancies. By leveraging extracellular adenosine—a tumor microenvironment metabolite—these cells activate P2RY13-dependent metabolic pathways, increasing mitochondrial ATP production by 2.5-fold and prolonging cytotoxic activity Creative Biolabs' lentiviral vector development services streamline the integration of such genetic circuits.
Induced Pluripotent Stem Cell (iPSC)-Derived Hepatocytes with Modulated P2RY13 Signaling
Creative Biolabs offers iPSC-derived hepatocytes with modulated P2RY13 signaling development services. iPSCs differentiated into hepatocytes and transfected with P2RY13 regulatory elements show restored lipid homeostasis in non-alcoholic steatohepatitis (NASH) models. These cells reduce hepatic triglyceride accumulation by 60% through P2RY13-mediated suppression of de novo lipogenesis. Creative Biolabs' endoderm-directed differentiation protocols and RNA sequencing services ensure lineage fidelity and functional validation for such applications.
To explore how these strategies can be tailored to your P2RY13-targeted programs, engage our multidisciplinary team for protocol optimization, in vivo validation, and regulatory guidance. to schedule a technical consultation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
