Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y14 |
| Gene Name | P2RY14 |
| Uniprot | Q15391 (Human); Q9ESG6 (Mouse) |
| Synonym | P2Y14; BPR105; GPR105; P2Y purinoceptor 14; G protein coupled receptor for UDP-glucose; G-protein coupled receptor 105; P2Y(14) receptor; P2Y14 receptor; UDP-glucose receptor; purinergic receptor P2Y, G-protein coupled, 14 |
| Background | P2RY14 is encoded by P2RY14 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been reported to regulate a panoply of cell signaling and physiologic responses. P2RY14 is one of the eight-member family of nucleotide-activated P2Y receptors and it is activated by UDP-glucose and other nucleotide sugars. It is also known as UDP glucose receptor because UDP glucose, UDP galactose, and UDP-N-acetylglucosamine are identified as potent agonists of P2RY14. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX74 | NativeExtract™ Human P2RY14 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3373K | MemDX™ Membrane Protein Human P2RY14 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0994X | MemDX™ Membrane Protein Human P2RY14 (Purinergic receptor P2Y14) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
T***in: The tailored P2RY14 expression system delivered intact tertiary structure preservation.
08/Nov/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated siRNA Silencing of P2RY14 in Inflammatory Pathologies
Creative Biolabs offers AAV-mediated siRNA silencing services. Recombinant adeno-associated virus (AAV) vectors engineered with small interfering RNA (siRNA) payloads enable selective downregulation of P2RY14 expression in diseased tissues. For instance, preclinical studies demonstrate that AAV9-based delivery of P2RY14-targeting siRNAs effectively attenuates intestinal epithelial cell necroptosis in murine colitis models by suppressing RIPK1 transcription via cAMP/PKA/CREB axis modulation. Creative Biolabs' expertise in designing tissue-specific AAV serotypes ensures precise transduction of colonic epithelial cells while minimizing off-target effects, a critical consideration for clinical translation.
P2RY14 Gene Editing for Hyperactivation Mitigation
Creative Biolabs offers P2RY14 gene editing services. Gene editing systems optimized for single-nucleotide precision permit permanent inactivation of gain-of-function P2RY14 mutations linked to chronic inflammation. Creative Biolabs' proprietary screening platforms validate guide RNA specificity and off-target profiles, ensuring therapeutic accuracy.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY14 cell therapy. Please for more services.
Engineered Macrophages with P2RY14 Antagonist-Secreting Capabilities
Creative Biolabs offers engineered macrophages with P2RY14 antagonist-secreting capabilities development services. Autologous macrophages genetically modified to secrete P2RY14 antagonists, such as HDL-16, offer a sustained therapeutic effect in inflamed microenvironments. These cells are transduced with lentiviral vectors encoding antagonist expression cassettes under control of hypoxia-responsive promoters, enabling localized drug release in ischemic colonic regions. Creative Biolabs' immunofluorescence-based validation services rigorously assess antagonist secretion kinetics and target engagement in 3D organoid co-culture systems.
P2RY14-Inhibitory CAR-T Cells for Immune-Mediated Disease Control
Creative Biolabs offers P2RY14-inhibitory CAR-T cells development services for immune-mediated disease control. Chimeric antigen receptor (CAR)-T cells targeting extracellular P2RY14 epitopes exhibit potent immunosuppressive activity in autoimmune disorders. By fusing a P2RY14-specific single-chain variable fragment (scFv) to intracellular NFAT signaling domains, these CAR-T cells selectively deplete P2RY14-overexpressing immune cells while sparing healthy tissues. Creative Biolabs' vector production infrastructure accelerates the transition from preclinical validation to clinical-scale manufacturing.
The complexities of P2RY14-targeted gene and cell therapies demand unparalleled technical precision. Creative Biolabs' integrated platform combines AI-driven target validation, proprietary vector engineering, and translational assay development to de-risk your drug development pipeline. to design a bespoke strategy addressing your therapeutic goals.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
