Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y4 |
| Gene Name | P2RY4 |
| Uniprot | P51582 (Human); Q9JJS7 (Mouse) |
| Synonym | NRU; P2P; UNR; P2Y4; P2Y purinoceptor 4; pyrimidinergic receptor P2Y, G-protein coupled, 4; uridine nucleotide receptor |
| Background | P2RY4 is encoded by the P2RY4 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has proved to be the drug targets of approximately 34% of all modern medicinal drugs. It is one of the eight subtypes of G protein-coupled P2Y receptors (P2RY1, P2RY2, P2RY4, P2RY6, P2RY11, P2RY12, P2RY13, and P2RY14). P2RY4 possesses seven transmembrane alpha helices and uses uridine nucleotides as the preferred endogenous agonist. Meanwhile, P2RY4 is also known as uridine nucleotides receptor and is activated by UTP and ATP partially, but cannot be activated by UDP or ADP. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX81 | NativeExtract™ Human P2RY4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3470K | MemDX™ Membrane Protein Human P2RY4 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0996X | MemDX™ Membrane Protein Human P2RY4 (Pyrimidinergic receptor P2Y4) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
Fin***an: Rapid technical support streamlined our project timeline.
07/Apr/2023
Gi***n: Their gene-to-protein platform delivered P2RY4 with C-terminal His tags in 4 weeks.
18/Aug/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Adenoviral Vector-Mediated Agonist Delivery for P2RY4 Receptor Modulation
Creative Biolabs offers adenoviral vector-mediated agonist delivery services for P2RY4 receptor modulation. Adeno-associated virus (AAV) vectors engineered for tissue-specific tropism enable precise delivery of P2RY4-targeted therapeutic genes. Preclinical studies demonstrate that AAV vectors encoding P2RY4 agonists enhance receptor activation in degenerative neural models, modulating intracellular calcium signaling and reducing neuroinflammatory markers. For example, in murine models of neuroinflammation, P2RY4 agonist expression via AAV9 vectors improved neuronal survival by 40% compared to controls. Creative Biolabs' expertise in designing cell-specific AAV serotypes ensures optimized transduction efficiency for P2RY4-expressing tissues, a critical factor for clinical translation.
siRNA-Mediated P2RY4 Silencing for Hyperactive Receptor Phenotypes
Creative Biolabs offers siRNA-mediated P2RY4 silencing services for hyperactive receptor phenotypes. RNA interference (RNAi) strategies using small interfering RNAs (siRNAs) effectively silence aberrant P2RY4 overexpression linked to chronic inflammatory pathologies. Lipid nanoparticle-encapsulated siRNAs targeting P2RY4 mRNA reduced receptor activity by 65% in pancreatic cell lines, correlating with decreased pro-inflammatory cytokine release. Creative Biolabs' proprietary biodistribution analytics refine siRNA delivery to minimize off-target effects, ensuring therapeutic precision for conditions like pancreatitis or autoimmune disorders.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY4 cell therapy. Please for more services.
Hematopoietic Stem Cells for P2RY4 Receptor Engineering
Creative Biolabs offers hematopoietic stem cells development services for P2RY4 receptor engineering. Hematopoietic stem cells (HSCs) enable stable P2RY4 expression to restore dysregulated purinergic signaling in immune cells. In proof-of-concept studies, edited HSCs transplanted into immunodeficient mice exhibited enhanced macrophage-mediated debris clearance via P2RY4-driven phagocytosis pathways. Creative Biolabs' gene-editing platforms facilitate knock-in/knockout modifications with >90% efficiency, accelerating therapeutic development for metabolic or neurodegenerative diseases.
Chimeric Antigen Receptor (CAR) Macrophages Targeting P2RY4-Positive Microenvironments
Creative Biolabs offers CAR macrophages development services targeting P2RY4-positive microenvironments. CAR macrophages engineered to overexpress P2RY4 receptors selectively infiltrate inflamed tissues, leveraging endogenous ATP gradients to amplify anti-inflammatory responses. In vitro, these cells reduced TNF-α secretion by 50% in synovial fluid samples from arthritis models. Creative Biolabs' immunofluorescence-based validation protocols ensure robust receptor expression and functional activity, critical for scaling adoptive cell therapies.
Creative Biolabs' end-to-end solutions provide the technical rigor and regulatory compliance required for preclinical success. to discuss customized strategies for optimizing P2RY4-targeted gene or cell therapies.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
