Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y6 |
| Gene Name | P2RY6 |
| Uniprot | Q15077 (Human); Q9ERK9 (Mouse) |
| Synonym | P2Y6; P2Y purinoceptor 6; G-coupled nucleotide receptor; P2 purinoceptor; P2Y6 receptor; pyrimidinergic receptor P2Y, G-protein coupled, 6 |
| Background | P2RY6 is encoded by the P2RY6 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is the largest family of membrane proteins in the human genome and the richest source of drug targets for the academia and pharmaceutic industry. It is one of the eight subtypes of P2Y G protein-coupled receptors, which are activated to UDP, UTP, and ADP, but are not activated by ATP. Like other receptors of the GPCR family, P2RY6 possesses seven transmembrane domains and the N terminal region contains an asparagine liked glycosylation sites, the C terminal region has two phosphorylation sites. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX80 | NativeExtract™ Human P2RY6 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3330K | MemDX™ Membrane Protein Human P2RY6 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0998X | MemDX™ Membrane Protein Human P2RY6 (Pyrimidinergic receptor P2Y6) with N-GST tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0997X | MemDX™ Membrane Protein Human P2RY6 (Pyrimidinergic receptor P2Y6) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
Ly***der: Batch-to-batch consistency ensures reproducible results in complex assays.
25/Sep/2023
O***n: Custom modifications delivered promptly, exceeding expectations.
06/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated P2RY6 Receptor Knockdown
Creative Biolabs offers AAV-mediated P2RY6 receptor knockdown services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable selective silencing of P2RY6 in pathological niches, such as chronic inflammatory tissues. For instance, AAV9 serotypes coupled with shRNA payloads have demonstrated >70% P2RY6 mRNA suppression in hepatic stellate cells, attenuating fibrogenic signaling in preclinical cirrhosis models. Creative Biolabs' expertise in viral vector design ensures optimized delivery efficiency and minimal off-target transcriptome perturbation, a critical consideration for clinical translation.
P2RY6 Genome Editing for Metabolic Dysregulation Correction
Creative Biolabs offers P2RY6 genome editing services for metabolic dysregulation correction. Ribonucleoprotein complexes, delivered via lipid nanoparticles, allow precise disruption of gain-of-function P2RY6 mutations linked to hyperinsulinemia. Recent studies achieved 98% allelic editing efficiency in pancreatic β-cells, restoring glucose-responsive insulin secretion in diabetic murine models. Creative Biolabs' end-to-end screening platforms accelerate the identification of high-fidelity guide RNAs, minimizing unintended genomic rearrangements during therapeutic intervention.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY6 cell therapy. Please for more services.
Chimeric Antigen Receptor (CAR) Macrophages for P2RY6+ Tumor Microenvironment Remodeling
Creative Biolabs offers CAR macrophages development services for P2RY6+ tumor microenvironment remodeling. CAR macrophages expressing P2RY6-specific scFv domains exhibit enhanced phagocytic activity against immunosuppressive tumor cells. In glioblastoma models, these engineered cells reduced adenosine-mediated T-cell exhaustion by 60%, synergizing with checkpoint inhibitors. Creative Biolabs' immunofluorescence imaging pipelines validate target engagement and intracellular signaling dynamics, ensuring functional CAR construct validation.
P2RY6-Antagonizing Mesenchymal Stem Cell (MSC) Infusions for Fibrotic Disease Mitigation
Creative Biolabs offers P2RY6-antagonizing MSC infusions development services for fibrotic disease mitigation. MSCs transfected with dominant-negative P2RY6 variants secrete decoy receptors that sequester extracellular UDP, a P2RY6 ligand driving collagen deposition. In pulmonary fibrosis trials, this approach decreased hydroxyproline content by 45% while preserving endogenous epithelial repair mechanisms. Creative Biolabs' proprietary cell banking systems guarantee >95% viability for scalable production.
Creative Biolabs' integrated platforms—spanning gene-editing analytics, viral vector optimization, and CAR cell validation—empower researchers to overcome technical bottlenecks in P2RY6 modulation. to design customized gene or cell therapy pipelines, leveraging 20+ years of translational expertise in purinergic receptor biology.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
