Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y8 |
| Gene Name | P2RY8 |
| Uniprot | Q86VZ1 (Human) |
| Synonym | P2Y8; P2Y purinoceptor 8; G-protein coupled purinergic receptor P2Y8; purinergic receptor P2Y, G-protein coupled, 8; purinergic receptor P2Y8 |
| Background | P2RY8 is encoded by the P2RY8 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is the largest family of membrane-bound receptors and also the targets of many drugs. It is one of the nigh subtypes of purinergic receptors (P2RY1, P2RY2, P2RY4, P2RY6, P2RY8, P2RY11, P2RY12, P2RY13, and P2RY14). P2RY8 possesses seven transmembrane alpha helices as other GPCRs and is activated by adenosine and uridine nucleotides. However, the expression profile of P2RY8 has been rarely documented in humans. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX79 | NativeExtract™ Human P2RY8 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3446K | MemDX™ Membrane Protein Human P2RY8 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0999X | MemDX™ Membrane Protein Human P2RY8 (P2Y receptor family member 8) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
Cal***pe: Tailored P2RY8 production met exact specifications (His-tag, solubilization buffers).
08/Jun/2023
El***n: Technical support provided real-time purification optimization.
13/Dec/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Correction of Pathogenic P2RY8 Variants
Creative Biolabs offers correction of pathogenic P2RY8 variants services. Somatic mutations in P2RY8, such as those identified in SLE patients, impair receptor function and exacerbate B-cell hyperactivity. Genome editing enables precise correction of these variants, restoring P2RY8-mediated migratory inhibition in dysregulated B cells. Creative Biolabs' expertise in genotyping and site-specific mutagenesis supports the design of guide RNAs and validation assays to ensure allelic fidelity, critical for preclinical translation. This approach may mitigate autoimmune pathology by re-establishing B-cell tolerance mechanisms.
Recombinant AAV Delivery for P2RY8 Expression Reconstitution
Creative Biolabs offers recombinant AAV delivery services for P2RY8 expression reconstitution. Adeno-associated virus (AAV) vectors engineered with B-cell-specific promoters can deliver wild-type P2RY8 to offset receptor deficiency in autoimmune microenvironments. Preclinical studies demonstrate that localized overexpression of P2RY8 suppresses aberrant B-cell activation and reduces autoantibody production. Creative Biolabs' cell-specific viral vector platforms enable tailored AAV designs, optimizing transduction efficiency while minimizing off-target effects. Such strategies hold promise for SLE and related disorders characterized by P2RY8 pathway dysfunction.
RNA Interference for Downstream Signal Modulation
Creative Biolabs offers RNA interference services for downstream signal modulation. Small interfering RNAs (siRNAs) targeting overactive Gα13-coupled pathways downstream of mutated P2RY8 can normalize B-cell migration. This indirect modulation compensates for receptor loss-of-function, offering therapeutic synergy with gene replacement strategies. Creative Biolabs' gene expression analysis services provide pharmacokinetic and biodistribution insights to refine siRNA dosing regimens.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY8 cell therapy. Please for more services.
P2RY8-Engineered Regulatory T Cells (Tregs) for Immune Modulation
Creative Biolabs offers P2RY8-engineered Tregs development services for immune modulation. Autologous Tregs transduced with P2RY8-expressing constructs exhibit enhanced immunosuppressive activity in inflamed tissues. These cells selectively migrate to sites of B-cell hyperactivity, leveraging P2RY8's intrinsic role in chemotaxis inhibition to block pathogenic lymphocyte infiltration. Creative Biolabs' immunofluorescence and imaging services enable real-time tracking of engineered Tregs, ensuring spatial precision in therapeutic delivery.
Chimeric Antigen Receptor (CAR) Macrophages Targeting P2RY8-Dysregulated B Cells
Creative Biolabs offers CAR macrophages development services targeting P2RY8-dysregulated B cells. CAR macrophages engineered to recognize P2RY8-deficient B cells selectively phagocytose autoreactive populations, synergizing with endogenous immune checkpoints. This approach capitalizes on P2RY8's biomarker potential in identifying disease-progressing B-cell subsets. Creative Biolabs' cell-specific viral vector systems ensure robust CAR expression, while transcriptomic profiling validates target engagement specificity.
P2RY8-Boosted Hematopoietic Stem Cell (HSC) Transplants
Creative Biolabs offers P2RY8-boosted HSC transplants development services. HSCs modified to overexpress P2RY8 generate self-tolerant B-cell progeny, resetting immune homeostasis in autoimmune patients. Creative Biolabs' genetic variation analysis services identify optimal donor-recipient HLA matching, enhancing engraftment success.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
