Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsP2X purinoceptors are the ATP-gated cation channels which consist of two transmembrane domains, a large extracellular loop contained ATP-binding site, and intracellular carboxyl and amino termini. They are activated by binding to extracellular ATP thereby mediating the permeability of cation such as Ca2+, Na+, and K+. P2X purinoceptors are widely expressed in most cell types including neurons, leukocytes, blood platelets, smooth muscle cells. They are involved in the physiological processes, including mediating fast ATP-dependent synaptic transmission and action potential propagation, contraction of smooth muscle cells, platelet aggregation, macrophage activation, mediation of nociception, and apoptosis. In addition, P2X purinoceptors can act as the therapeutic target for some diseases. It has been reported that P2X7 inhibitor is a potential drug for the treatment of rheumatoid arthritis and chronic obstructive pulmonary disease.
Here show P2X purinoceptors in humans including P2RX1-P2RX7. The P2X purinoceptors subtypes are expressed on specific cell types. For example, P2RX1 is particularly expressed in smooth muscle cells, P2RX2 is widely present in the nervous system. However, more than one subunit can be also expressed in most cell types. For example, it is found that P2X2 and P2X3 subunits are commonly co-expressed in sensory neurons.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
