Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsP2Y receptors are a class of G-protein-coupled receptors for extracellular nucleotides expressed in almost all human cells. P2Y receptors are widely expressed and play important roles in physiology and pathophysiology. The ADP-induced platelet aggregation is mediated by P2Y1 and P2Y12 receptors, which are used for the prevention and therapy of cardiovascular events. In addition, P2Y receptors are crucial to the nervous system. Adenine nucleotides regulate neuronal activity and neuronal fibre outgrowth by activating the P2Y1 receptors and control migration of microglia by the P2Y12 receptors. UDP stimulates microglial phagocytosis by activating the P2Y6 receptors. Interestingly, recent findings reveal a prominent role for P2Y2 receptors in Alzheimer's disease pathology. The P2Y receptor subtypes are highly diverse in their amino acid sequences and their pharmacological profiles. Selective receptor ligands have been developed for the pharmacological characterization of the receptor subtypes. The study of three-dimensional crystal structures of the P2Y1 and P2Y12 receptors will facilitate the development of therapeutic agents that selectively target P2Y receptors.
Fig.1 Simplified illustration of extracellular purinergic signaling.
Based on pharmacology, signal transduction, and structural similarity, P2Y receptors are divided into two subfamilies. Receptors of the first subfamily (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11) are coupled via the Gq-proteins to stimulate phospholipase C followed by increases in inositol phosphates and mobilization of Ca2+ from intracellular stores. In contrast, the P2Y12 receptor subfamily (P2Y12, P2Y13, and P2Y14) signals primarily by activating the Gi proteins and inhibiting the adenylate cyclase activity or controlling the ion channel activity. The non-consecutive numbering of the mammalian P2Y receptors is due to the assignment of the P2Y nomenclature to species homologs or to proteins that has not been demonstrated as an extracellular nucleotide receptor function.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
