Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsPannexin (PANX) family is a group of transmembrane channels present in the vertebrate that is homology to the invertebrate innexins responsible for gap connections. Similar to innexins structure, PANXs also have transmembrane domains, 2 extracellular and 1 intracellular N- and C-terminal tails loop. It has identified that PANXs can be assembled to hemichannels allowing the ions and small molecules including ATP, glutamate, prostaglandins, and others typically below 1-2 kDa, as well as the influx of ions such as Na+ and Ca2+ traffic to the extracellular space. PANXs expressed in the central nervous system are associated with the sensory processing, hippocampal plasticity, and propagation of calcium waves. Moreover, PANXs have been revealed an association with the pathological processes such as neural damage after ischemia, cardiovascular disease, diabetes. Besides, PANX1 has been shown to be involved in early stages of innate immunity through controlling interleukin-1β release by the ATP-gated P2X7 receptor.
Here shows PANXs in humans including PANX1, PANX2, and PANX3, encoded by PANX1, PANX2, and PANX3 genes, respectively. And studies have identified only three PANX genes in mammals so far. PANX1 is widely expressed in many mammalian tissues, especially in the brain, while PANX2 and PANX3 seem to be more restricted in their expression. It has been reported that PANX1 plays a diverse role in many biological processes such as the propagation of calcium waves, regulation of vascular tone, taste-bud function, apoptosis and so on. PANX2 has been revealed a regulator of differentiation of neurons. PANX3 is involved in the regulation of chondrocytes and osteoblasts differentiation as well as sperm maturation and transport.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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