PAR3 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of F2RL2

Protein Name	Coagulation factor II thrombin receptor like 2
Gene Name	F2RL2
Uniprot	O00254 (Human); O08675 (Mouse)
Synonym	F2RL2; PAR3; PAR-3; proteinase-activated receptor 3; Coagulation factor II receptor-like 2 (protease-actovated receptor 3); protease-activated receptor 3; thrombin receptor-like 2
Background	PAR3, also known as coagulation factor II receptor-like 2 (F2RL2) or thrombin receptor-like 2, is a protein of 374 amino acids and has approximately 42.5 kDa molecular mass. In humans, it is encoded by the gene F2RL2 located at the chromosome 5q13.3. PAR3 belongs to the protease-activated receptor (PAR) family, a subfamily of seven transmembrane G protein-coupled receptor, and is activated by thrombin.

F2RL2 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX71	NativeExtract™ Human F2RL2 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MPX3366K	MemDX™ Membrane Protein Human F2RL2 Expressed in vitro E.coli expression system, Full Length of Mature Protein	E.coli cell-free	Full length	Detergent
MP0346X	MemDX™ Membrane Protein Human F2RL2 (Coagulation factor II thrombin receptor like 2) for Antibody Discovery	Wheat germ cell-free	Full length	Liposome
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Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

F2RL2 Drug Discovery and Development

F2RL2 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-F2RL2 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

F2RL2 Gene Therapy Development

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Synthetic Gene Circuits

Creative Biolabs offers synthetic gene circuits services. Engineered biological constructs represent sophisticated frameworks designed to govern the transcriptional activity of specific genetic loci, notably the F2RL2 gene, in a manner contingent upon pre-defined intracellular or extracellular stimuli. Consider, for instance, the intricate architecture of a synthetic genetic circuit; such a system could conceivably be calibrated to initiate the expression of F2RL2 exclusively when confronted with the biochemical signature of a particular disease biomarker. This meticulously orchestrated molecular response, therefore, portends the development of therapeutic modalities characterized by heightened specificity and finely tuned regulatory control. Consequently, this approach might offer a substantial advancement over conventional, less targeted interventions.

Epigenetic Modifiers

Creative Biolabs offers epigenetic modifiers services. The intricate landscape of epigenetic modifications, encompassing phenomena such as DNA methylation and histone post-translational alterations, exerts a profound influence over the transcriptional activity of specific genes. Consequently, judicious manipulation of these epigenetic marks presents a compelling strategy for the precise control of gene expression. Indeed, by leveraging exogenous small molecules or employing alternative sophisticated methodologies, researchers can intentionally modulate the epigenetic state localized to the F2RL2 gene. Such targeted interventions might subsequently lead to either the upregulation or downregulation of its expression, precisely as necessitated by a particular research objective or therapeutic aim. This capacity for finely tuned regulation arguably holds significant promise for future biotechnological applications.

Multi-gene Therapy

Creative Biolabs offers multi-gene therapy services. In specific biological contexts, F2RL2 dysfunction may not arise in isolation; rather, its aberrant activity could conceivably be intricately linked with the perturbation of other proximal genes or interconnected signaling pathways. Consequently, a multi-gene therapeutic strategy, one engineered to address several genetic targets concurrently, might prove to be a more efficacious intervention. This sophisticated approach can be realized through various technical modalities. For instance, the co-delivery of multiple therapeutic transgenes utilizing a singular, carefully designed viral or non-viral vector represents one viable avenue. Alternatively, the judicious amalgamation of distinct gene therapy methodologies could also yield a synergistically beneficial outcome, potentially offering enhanced clinical efficacy.

F2RL2 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of F2RL2 cell therapy. Please inquire with us for more services.

Gene-Modified Cell Therapy

Creative Biolabs offers gene-modified cell therapy services. A sophisticated therapeutic modality involves the ex vivo manipulation of patient-derived cells. This process typically begins with the extraction of autologous cells, which are then genetically modified to either induce or augment the expression of F2RL2. Following these intricate genetic alterations, the engineered cellular population is then meticulously reintroduced into the patient. Such modifications can be precisely accomplished through established gene addition methodologies or via advanced gene editing techniques. This targeted cellular engineering might conceivably amplify their intrinsic anti-tumorigenic or anti-inflammatory capacities, thereby offering a potentially potent therapeutic avenue.

Immune Cell Engineering

Creative Biolabs offers immune cell engineering services. The sophisticated engineering of immune cell populations, exemplified by chimeric antigen receptor T (CAR-T) cells, holds considerable promise when strategically directed against F2RL2 or its cognate downstream signaling cascades. This innovative approach may facilitate the precise redirection of these therapeutic immune cells. Consequently, they could be programmatically enabled to specifically engage and subsequently eliminate aberrant cellular entities, such as malignant neoplastic cells or other pathologically altered cells, which conspicuously express either F2RL2 itself or closely associated molecular determinants. This highly targeted recognition mechanism potentially offers a refined method for selective cellular ablation.

In Vivo Animal Models

Creative Biolabs offers in vivo animal models development services. The indispensable role of animal models in bridging the chasm between fundamental laboratory investigations and eventual clinical translation cannot be overstated, particularly concerning the evaluation of F2RL2-targeted cell therapies. These in vivo systems offer a critical platform for rigorously assessing both the efficacy and the safety profiles of novel therapeutic interventions. Such preclinical findings, therefore, serve as foundational evidence, perhaps informing the progression of these innovative therapies toward human trials.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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