Peptide transporter (PTR), also known as solute carrier family 15 (SLC15) or proton-dependent oligopeptide transporter (POT), belongs to the major facilitator family (MFS) of transporters as they typically contain 12-18 transmembrane domains which derive their energy of transport from the import of proton. Studies have shown that they could provide amino acids and nitrogen in all living organisms except archaea. To date, multiple transporters have been identified, including but not limited to SLC15A1 (PEPT1), SLC15A2 (PEPT2), and SLC15A4 (PHT1). It has been reported that a common feature of the PTR family is that the carriers couple substrate movement across the membranes to movement of protons down an inwardly directed electrochemical proton gradient, allowing transport of peptides against a substrate gradient. Furthermore, SLC15A1 and SLC15A2 not only transport a wide range of di-and tripeptides accounting for more than 8000 different substrates but also transport peptidomimetics with pharmacological and clinical relevance.
Here, we have described in detail of members of the solute carrier family 15, including SLC15A1, SLC15A2, and SLC15A4. To learn more detailed information, please click the links below.
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