pH-sensitive bioactive peptides are of great importance for biomedical research and disease treatments. With Ph.D. level scientists and over a decade of experience in applying phage display technology, Creative Biolabs has developed a powerful phage display platform for phage display library construction and phage display library screening. We are proud to introduce our characteristic service of pH-sensitive bioactive peptide discovery to all our global customers.
Bioactive peptides are a group of peptides which have specific biological functions, such as glucagon-like peptide-1, ghrelin, which is used for the control of diabetes and to treat obesity, respectively. Gastrin-releasing peptide is used in cancer treatments, and defensin is used as an antimicrobial agent. At present, hundreds of these peptides have been isolated from different biological sources. The number of pharmacologically active peptides under development for the prevention and treatment of human disorders has increased rapidly due to their advantages over small molecules and proteins. Researchers have found that the extracellular pH of some solid tumor is consistently lower as compared to the pH = 7.2~7.4 in normal tissues/organs. For cancer treatment, liposomes have shown considerable promise as vehicles for the delivery of small molecular mass drugs to tumors. Such efforts for accelerating drug release have largely focused on the development of pH-sensitive peptides. Recently, pH-dependent peptides that mimic viral fusion peptides have been designed to enable release of liposome contents at acidic pHs. The peptides seem to be in random coil conformations at neutral pH, but at pH 5, the peptides predominantly turn into amphipathic helices. As a consequence of this conformational transition, the function of these peptides changes largely.
Fig.1 LAPTM4B guided AP2H‐hydrazon‐DOX internalization and pH mediated drug release process (Jin et al. 2015).
Powered by our advanced phage display platform and experienced technical personnel, Creative Biolabs has developed lots of strategies for isolation of pH-sensitive bioactive peptide based on our diverse phage display libraries. Custom synthetic phage display peptide libraries and diverse premade phage display peptide libraries can be used for the selection of pH-sensitive bioactive peptide. Our scientists can rapidly isolate pH-sensitive bioactive peptide by applying tailored selection strategies.
For over a decade, Creative Biolabs is dedicated to providing our customers with high-quality services in the field of phage display. In the field of applying phage display technology and next-generation sequencing (NGS) technology, Creative Biolabs has accumulated extensive experiences. We can offer high-quality customized pH-sensitive bioactive peptide discovery service by adjusting protocols to meet even the most specific requirements.
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