Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsPiezo-type mechanosensitive ion channel family is a group of integral membrane proteins that contain 24-40 transmembrane domains. It has been shown that piezo proteins are the mechanosensitive ion channels regulating mechanosensory transduction in numerous eukaryotic cell types. Piezo proteins open and allow positively charged ions including calcium to flow into the cell when exposed to stimuli such as shear stress and membrane stretch. Mechanosensory transduction mediated by piezo proteins plays a very important role in many biological processes including sensing touch, sound waves, regulation of vascular tone, regulating urine flow and bladder distention. Moreover, they are also associated with the regulation of cellular growth, development, migration, and volume. In addition, piezo proteins are involved in a variety of disorders including hereditary xerocytosis, muscular contracture syndromes, Alzheimer disease.
Here show two isoforms of piezo family in humans, PIEZO1 and PIEZO2. They are very large proteins with about 2521 and 2752 amino acids encoded by human gene PIEZO1 and PIEZO2, respectively. The two isoforms share ~50% homology. PIEZO1 is widely expressed in skin, bladder, kidney, lung, endothelial cells, erythrocytes, and periodontal ligament cells. PIEZO2 is primarily expressed in sensory trigeminal ganglia (TG) and dorsal root ganglia (DRG), Merkel cells, lung, and bladder.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
