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HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
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HighlightsInwardly rectifying potassium channels (variously classified as “Kir”, “IRK” or “KCNJ” proteins) are a specific subset of potassium selective ion channels. They have the ability to generate ion channels that act as bio-diodes in cell membranes, conducting large K+ currents at membrane potentials more negative than the reversal potential for potassium (EK) while the outward flux of ions more positive to EK is reduced. The inwardly rectifying properties of these channels are the result of block by intracellular Mg2+ and polyamines. Gating (opening and closing) of KCNJ channels is voltage-independent, however, channel activity is often directly regulated by extracellular or intracellular second messengers. To date, sixteen KCNJ proteins have been identified in various mammalian cell types and they are also found in plants. It has been reported that these channels are expressed in a wide variety of cells including skeletal, cardiac, and vascular myocytes, neurons, and pancreatic β-cells. What’s more, they play numerous key physiological roles, particularly in stabilizing the resting membrane potential, regulating K+ ion flux across cellular membranes, and regulation of cellular excitability.
Here, we have described in details of members of the KCNJ proteins family, which including but not limited to ATP-sensitive inward rectifier potassium channel 1, ATP-sensitive inward rectifier potassium channel 10, and ATP-sensitive inward rectifier potassium channel 11. To learn more detailed information, please click the links below.
| Human KCNJ Protein Members | |||
| KCNJ1 | KCNJ10 | KCNJ11 | KCNJ12 |
| KCNJ13 | KCNJ15 | KCNJ16 | KCNJ18 |
| KCNJ2 | KCNJ3 | KCNJ4 | KCNJ5 |
| KCNJ6 | KCNJ8 | KCNJ9 | |
With the help of our advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
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