The potassium channel subfamily K, also known as the two-pore-domain potassium channel (K2P), is composed of 15 members what are known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the unique structure of four membrane-spanning domains and two pore-forming loops per subunit. Studies have shown that the expression of several KCNK family members was detected throughout the cardiovascular, central nervous, gastrointestinal, and genitourinary system. Many neurotransmitters and neuromodulators act via G protein-coupled receptors to close KCNK channels and thereby regulate neuronal activity. Furthermore, it has been reported that K2P currents contribute to a large variety of physiological functions, including regulation of cardiac rhythm, mechanical stress, blood pressure, neuroprotection, anesthesia, apoptosis, and sensation of oxygen tension, taste, and temperature.
Here, we have described in details of members of the KCNK protein family, which including but not limited to potassium channel subfamily K member 1, potassium channel subfamily K member 10, and potassium channel subfamily K member 12. To learn more detailed information, please click the links below.
|Human KCNK Protein Members|
Aided by our advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. To get more detailed information, please feel free to contact us.
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.