Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels consist of a series of intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Unlikely other members of the voltage-gated channel superfamily, they are activated upon hyperpolarization, near the membrane resting potential of excitable cells. Currently, four mammalian HCN channels subtypes (HCN1-HCN4) have been determined. As the name implies, the HCN family are cation channels that are activated upon hyperpolarization and serve important functions in the nervous system, including regulation of neurotransmitter release, initiation of rhythmic activity by acting as pacemakers and dampening of dendritic excitability. Studies have suggested that the potassium/sodium HCN channels are widely expressed in excitable tissues, where they play a key role in the initiation and regulation of the rhythmic activity. What’s more, HCN channels display a weak cation selectivity but under physiological conditions, due to the electrochemical gradient, carry a Na+ inward current when they open.
Here, we have described in detail of members of the potassium/sodium HCN channel family, which including but not limited to potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 and potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. To learn more detailed information, please click the links below.
Aided by our advanced MemDX™ membrane protein production platform, Creative Biolabs is confident in offering diverse target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
