Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Potassium voltage-gated channel subfamily E (Kv5 channels) is composed of membrane-spanning proteins that interact with ion channels and modify their properties. Their structure consists of a single membrane-spanning α helix, and extra- and intracellular N and C termini, respectively. To date, five human genes have been identified and denoted KCNE1-5. They cannot generate current themselves, but they have the ability to alter the behavior and facilitate the native functions of certain ion channels. Studies have shown that different KCNE isoforms are widely and differentially expressed in muscular and neuronal tissues as well as in epithelial cells. What’s more, it has been proved that mutations in KCNE genes could lead to disruptions of diverse physiological systems and diseases such as cardiac arrhythmias, deafness, and paralysis.
Here, we have described in detail of members of the VGKC subfamily E, which including but not limited to potassium voltage-gated channel subfamily E member 1, potassium voltage-gated channel subfamily E member 2, potassium voltage-gated channel subfamily E member 3 and potassium voltage-gated channel subfamily E member 4. To learn more detailed information, please click the links below.
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