Potassium voltage-gated channel subfamily KQT, also known as KQT-like channels (KCNQ channels), are members of a family of voltage-dependent potassium-selective channels that are involved in the control of cellular excitability. They possess no tetramerization domain which differs from voltage-gated 6TM helix channels. Consequently, they rely on interaction with accessory subunits or form heterotetramers with other members of the family. Currently, 5 members of the KCNQ family have been identified. It has been reported that the expression of KCNQ proteins has been found in diverse tissues, such as heart, brain, pancreas, lung, placenta, and ear. Remarkably, mutations in four of the five known members of this family have been associated with different hereditary human disorders. While mutations in the KCNQ1 subunit (KvQT1) lead to arrhythmia in the human long QT syndrome, mutations in KCNQ2 or KCNQ3 are associated with a benign form of epilepsy. It has also been shown that KCNQ4 is mutated in a dominant form of progressive hearing loss.
Here, we have described in detail of members of the KCNQ protein family, which includes but not limited to potassium voltage-gated channel subfamily KQT member 1, potassium voltage-gated channel subfamily KQT member 2, and potassium voltage-gated channel subfamily KQT member 3. To learn more detailed information, please click the links below.
Based on advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.