Potassium voltage-gated channel subfamily KQT, also known as KQT-like channels (KCNQ channels), are members of a family of voltage-dependent potassium-selective channels that are involved in the control of cellular excitability. They possess no tetramerization domain which differs from voltage-gated 6TM helix channels. Consequently, they rely on interaction with accessory subunits or form heterotetramers with other members of the family. Currently, 5 members of the KCNQ family have been identified. It has been reported that the expression of KCNQ proteins has been found in diverse tissues, such as heart, brain, pancreas, lung, placenta, and ear. Remarkably, mutations in four of the five known members of this family have been associated with different hereditary human disorders. While mutations in the KCNQ1 subunit (KvQT1) lead to arrhythmia in the human long QT syndrome, mutations in KCNQ2 or KCNQ3 are associated with a benign form of epilepsy. It has also been shown that KCNQ4 is mutated in a dominant form of progressive hearing loss.
Here, we have described in detail of members of the KCNQ protein family, which includes but not limited to potassium voltage-gated channel subfamily KQT member 1, potassium voltage-gated channel subfamily KQT member 2, and potassium voltage-gated channel subfamily KQT member 3. To learn more detailed information, please click the links below.
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