PreciAbSeq

Unlocking Antibody Secrets with Precision Sequencing

Empowered by: Database Assisted Shotgun Sequencing (DASS) Technology

Prominent Perks

Through high-precision de novo sequencing, Creative Biolabs can rapidly characterize antibodies, expediting the selection of candidates with superior binding affinities and potencies, accelerating the development process.

Expediting Antibody Breakthroughs

Leucine/Isoleucine Discrimination

Creative Biolabs has achieved the precise identification of leucine (Leu) and isoleucine (Ile) by mass spectrometry, which can expedite your project schedule by avoiding the need to express different variants, leading to substantial cost savings.

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Isobaric Amino Acids Discrimination

Unlike other MS-based methods, our DASS technology stands out for its exceptional ability to discriminate most isobaric amino acid combinations, which ensures more accurate and reliable results in recognizing complex antibody sequences.

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Manual Sequence Curation

At Creative Biolabs, our experienced scientist can determine the sequence with higher accuracy by manual-checking rather than relying on the automatic algorithms only — particularly when your antibody has difficult positions with low overlap or isobaric exchanges.

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Intact Mass Validation

At Creative Biolabs, intact mass validation is performed to ensure that your antibody is functional right from the first attempt. Intact mass validation is an integral part of antibody sequencing, which ensures that no amino acid is missing, and no mutation is overlooked.

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Our Guarantee

We guarantee full coverage of the VJ and VDJ region, multiple cleavages with at least 4 different peptides covering each amino acid position, sequence validation ensuring the determined sequences match measured intact masses of heavy (± 1.8 Da) and light chain (± 1.2 Da), and fast delivery within 10 working days; additional 2-3 weeks only if Ile/Leu discrimination is required.