As a well-recognized pioneer in the field of antibody discovery, our talented scientific team has been constantly striving for facilitating custom projects and realizing the goal of our clients. Currently, Creative Biolabs has tailored a full portfolio of well-established premade human antibody libraries for de novo discovery of superior anti-membrane protein antibodies.
Membrane proteins take irreplaceable part in all kinds of physiological cellular functions, constituting one most popular class of therapeutic targets (of 40%-50% current marketed drugs). Nowadays, there have emerged plenty of antibody drugs against membrane proteins in market, for treatment of cancer, infectious diseases, autoimmune diseases, etc. Numerous candidates are still under development phase. Anti-membrane protein antibodies, in contrast to small molecular agents, exert increased specificity, affinity, lower toxicity and most important, are able to elicit diverse functional properties via interaction with body immune system.
As a powerful tool to screen and select good binders from vast candidate pools, phage display has been successfully applied in the discovery and development of anti-membrane protein antibodies for therapeutic/diagnostic use. However, due to the difficulty in immunogen preparation and immunization, antibody development against membrane proteins is very challenging and time-consuming. Therefore, premade antibody library screening poses as an attractive alternative for direct discovery of antibodies against a variety of membrane proteins. With years of efforts, Creative Biolabs has integrated a comprehensive series of premade human antibody libraries of various format, as a powerful tool for anti-membrane protein antibody discovery. Our well-tailored libraries have overwhelming capacity and diversity capable of deriving good binders with 10 pM-10 nM affinity. A long list of success records can be tracked for whom we have generated high-quality antibodies.
|Library ID||Library Format||Library Source||Library Capacity|
|HuScL-3||Recombinant naïve scFv||Human||1.6×109|
|HuFabL-2||Naïve & synthetic Fab||Human||2.0×1010|
Highlight advantages of premade human antibody library screening for anti-membrane protein antibody discovery:
Creative Biolabs is professional in tailoring highly specific, highly affinitive antibodies targeting various membrane proteins. Of note, one-stop membrane protein immunogen preparation service is also available. Our scientists have extensive expertise in dealing with various GPCR immunogens, ion channel immunogens, and transporter immunogens. Please feel free to contact us for more details.