Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe solute carrier family 38 (SLC38) of probable sodium-coupled neutral amino acid transporter comprises 11 members in the human genome and closely related mammalian genomes. They are widely found in plants, animals, yeast, fungi, bacteria, archaea, unicellular eukaryotic protists, and slime molds. The SLC38 family belongs to the amino acid-polyamine-organocation family of transporters. All transporters in this family are Na+ dependent and mediate the efflux of small neutral amino acids. Therefore, they are particularly expressed in actively growing cells, or in cells undergoing significant amino acid metabolisms, such as kidney, liver, and brain. The SLC38 transporters are present in membranes that face intercellular space or blood vessels, but not in the apical membrane of absorptive epithelia. In the placenta, they play an important role in the transfer of amino acids to the fetus.
Fig.1 Proposed roles of SLC38 transporters in the liver. (Bröer, 2014)
SLC38 family transporters are highly regulated by stimuli such as amino acid depletion, osmolarity, hormones, and cell growth. Expression of SLC38 transporters during cell growth is essential because they allow the amino acids to enter the cells, whereas many other amino acid transporters are obligatory antiporters. They have been proposed as transceptors independent of their transport function. Transporters of the SLC38 family provide potential to treat disease states. Inhibition of SNAT2 could prevent ER stress in pancreatic beta cells, and inhibition of SNAT5 could be beneficial for myc-driven cancers. Development of specific inhibitors would be greatly facilitated by improving the structure of mammalian members of the SLC38 family.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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