Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Prokineticin receptor 1 |
| Protein Name | Prokineticin receptor 1 |
| Gene Name | PROKR1 |
| Uniprot | Q8TCW9 (Human); Q9JKL1 (Mouse) |
| Synonym | ZAQ; PKR1; GPR73; PK-R1; GPR73a; G protein-coupled receptor 73; G protein-coupled receptor ZAQ |
| Background | PROKR1 is encoded by the PROKR1 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is the largest known class of molecular targets with proven therapeutic value. It is one of the two subtypes of family A GPCRs (PROKR1 and PROKR2). Amino acids sequence indicates that PROKR1 and PROKR2 share 85% sequence identity. PROKR1 has seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loop regions as other GPCRs. Meanwhile, PROKR1 contains a nine-residue insert in the second intracellular loop and in the C terminal tail. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX392 | NativeExtract™ Human PROKR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3524K | MemDX™ Membrane Protein Human PROKR1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0749J | MemDX™ Membrane Protein Human PROKR1 (Prokineticin receptor 1) for Antibody Discovery | HEK293 cell | Full length | N/A |
| S01YF-0423-KX647 | MemDX™ Membrane Protein Human PROKR1 (1-62aa) Expressed in HEK293, C-Human Fc tag | HEK293 cell | Partial | N/A |
| Please contact us for more products or customization | ||||
I***de: Creative Biolabs delivered a tailored PROKR1 construct with superior membrane protein stability.
24/Sep/2023
L**a: Technical support ensured seamless integration into our workflow. Highly recommended.
04/Jun/2024
PROKR1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated PROKR1 Transcriptional Modulation
Creative Biolabs offers AAV-mediated PROKR1 transcriptional modulation services. Recombinant adeno-associated virus (AAV) vectors engineered for cell-specific delivery enable precise modulation of PROKR1 expression in target tissues. For instance, dual-promoter AAV systems can simultaneously silence hyperactive PROKR1 alleles in endocrine tumors while delivering therapeutic transgenes to restore downstream signaling homeostasis. Creative Biolabs' expertise in optimizing tropism-modified AAV capsids ensures selective transduction of PROKR1-enriched cellular populations, minimizing off-target effects. Our team can customize vectors with tissue-specific promoters (e.g., endocrine gland-selective promoters) to enhance therapeutic precision.
PROKR1 Promoter Editing
Creative Biolabs offers PROKR1 promoter editing services. Gene editing systems targeting regulatory regions upstream of PROKR1 allow fine-tuned control of its transcription. In preclinical osteoporosis models, transient activation of PROKR1 in mesenchymal stem cells has shown potential to amplify bone-forming pathways analogous to Wnt/β-catenin signaling enhancements. Creative Biolabs provides RNA libraries validated for PROKR1 promoter specificity and epigenetic modulation efficiency. Collaborative projects can integrate RNA sequencing to map edited transcriptional outcomes.
Creative Biolabs offers comprehensive and innovative services to drive the development of PROKR1 cell therapy. Please for more services.
PROKR1-Engineered Mesenchymal Stem Cell (MSC) Implants
Creative Biolabs offers PROKR1-engineered MSC implants development services. Genetically modified MSCs overexpressing PROKR1 demonstrate enhanced migratory capacity toward sites of vascular injury, leveraging the receptor's endothelial chemotactic properties. Creative Biolabs' lentiviral transduction protocols achieve stable PROKR1 expression in primary MSCs, with functional validation via capillary tube formation assays. These cells show promise in preclinical angiogenesis models, particularly for endocrine tissue repair.
High-Resolution PROKR1 Localization Mapping
Creative Biolabs offers high-resolution PROKR1 localization mapping development services. Subcellular trafficking of PROKR1 in tumor microenvironments can be mapped using Creative Biolabs' anti-PROKR1 polyclonal antibodies, which enable quantitative immunofluorescence and super-resolution imaging. This technique revealed PROKR1 accumulation in nuclear membranes of hormone-resistant cancer cells, informing targeted protein degradation strategies. Partner with our imaging team to deploy these antibodies in spatial transcriptomics pipelines or drug screening assays.
Leverage our end-to-end solutions in viral vector design, gene editing, and cellular engineering to de-risk PROKR1-targeted therapeutic development. Our platform integrates mechanistic validation and clinical-grade manufacturing support. to schedule a technical consultation and access protocol templates optimized for PROKR1 pharmacology.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
