Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Prokineticin receptor 2 |
| Gene Name | PROKR2 |
| Uniprot | Q8NFJ6 (Human); Q8K458 (Mouse) |
| Synonym | HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3; G protein-coupled receptor 73-like 1; G-protein coupled receptor I5E; PK-R2 |
| Background | PROKR2 is encoded by the PROKR2 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is the largest single class trans-membrane proteins and is important regulator therapeutic drug targets of human physiology. It is one of the two subtypes of family A GPCRs (PROK1 and PROKR2). Amino acids sequence indicates that PROKR1 and PROKR2 share 85% sequence identity. PROKR2 is composed of 81 amino acids contains 10 cysteines forming five disulfide bridges. No structure of the PROKR1 or PROKR2 has been reported so far. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX65 | NativeExtract™ Human PROKR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3509K | MemDX™ Membrane Protein Human PROKR2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0854J | MemDX™ Membrane Protein Human PROKR2 (Prokineticin receptor 2) for Antibody Discovery | HEK293 cell | Full length | N/A |
| Please for more products or customization | ||||
I*y: Seamless integration into cell-based assays with reliable batch consistency accelerated our GPCR signaling studies.
09/Jul/2023
A***ra: A streamlined service from design to validation.
23/Mar/2024
PROKR2 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
Mutation Correction
Creative Biolabs offers mutation correction services. PROKR2 mutations disrupting G-protein coupling efficiency represent prime targets for interventions. By deploying precision gene-editing tools, pathogenic variants can be corrected to restore PROKR2 signaling integrity. This approach is particularly salient for disorders, where PROKR2 mutations compromise neuroendocrine functions. Creative Biolabs' gene-editing design platform ensures allele-specific targeting, minimizing off-site effects while maximizing therapeutic fidelity.
Adeno-Associated Virus (AAV)-Driven PROKR2 Overexpression
Creative Biolabs offers AAV-driven PROKR2 overexpression services. AAV vectors engineered with cell-specific promoters enable localized PROKR2 overexpression in neuronal populations. For instance, preclinical models demonstrate that PROKR2 activation in the suprachiasmatic nucleus normalizes circadian rhythm disruptions linked to anxiety phenotypes. Creative Biolabs' proprietary AAV serotypes achieve unparalleled tropism for PROKR2-expressing cells, a critical advancement for mitigating neuropsychiatric disorders.
RNA Interference for Metabolic Regulation
Creative Biolabs offers RNA interference services for metabolic regulation. Antisense oligonucleotides (ASOs) targeting PROKR2 mRNA mitigate hyperphagia and obesity in metabolic syndrome models. By transiently suppressing PROKR2 expression in hypothalamic neurons, this modality rebalances energy homeostasis without irreversible genomic alterations. Creative Biolabs' lipid-nanoparticle delivery systems enhance ASO bioavailability, ensuring robust target engagement.
Creative Biolabs offers comprehensive and innovative services to drive the development of PROKR2 cell therapy. Please for more services.
PROKR2+ Neural Stem Cell Transplantation
Creative Biolabs offers PROKR2+ neural stem cell transplantation services. Implanting PROKR2-overexpressing neural stem cells into circadian rhythm-disrupted brain regions rescues behavioral deficits in preclinical anxiety models. These cells secrete PROKR2 ligands to amplify endogenous signaling, synergizing with host neuronal networks. Creative Biolabs' differentiation protocols yield high-purity PROKR2+ lineages, essential for functional engraftment.
CAR-Macrophages for Immunomodulation
Creative Biolabs offers CAR-macrophages for immunomodulation development services. PROKR2's anti-inflammatory properties inspire CAR-macrophages engineered to overexpress the receptor in inflamed tissues. These cells bind PROKR2 ligands to suppress IL-12 production, attenuating chronic inflammation in metabolic disorders. Creative Biolabs' immunofluorescence imaging platforms validate receptor localization, ensuring therapeutic potency.
Optogenetic Control of PROKR2+ Sensory Neurons
Creative Biolabs offers optogenetic control of PROKR2+ sensory neurons services. PROKR2-Cre+ sensory neurons innervating deep fascial layers are ideal optogenetic targets for precision anti-inflammatory therapies. Blue light activation of CatCh-expressing neurons mimics acupuncture-induced vagal-adrenal anti-inflammatory responses, offering non-invasive alternatives for autoimmune conditions.
As pioneers in receptor-specific therapeutic design, Creative Biolabs provides end-to-end solutions—from gene-editing validation to AAV optimization and functional phenotyping. to tailor these cutting-edge strategies to your PROKR2 program's unique requirements.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
