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VH 032 Amine Hydrochloride (CAT#: PRLG-002)

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Specifications
Product Description VH 032 amine hydrochloride is a compound that binds to von Hippel-Lindau (VHL) E3 ligase and used in PROTAC® pathway. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.
Molecular Formula C22H31ClN4O3S∙(HCl)
Molecular Weight (Da) 467.02
Chemical Name (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride
Chemical Structure
Purity 98%
Solubility 40 mg/mL in DMSO
Size 5 mg
Physical State Lyophilized white powder
Storage The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. Store solutions at -80°C for up to 6 months or -20°C for up to 1 month.
Target Information
Target Name von Hippel-Lindau disease tumor suppressor
Alternative Names HRCA1; RCA11; pVHL; VHL
Introduction VHL is involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It acts as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions.
Gene ID 7428
UniProt ID P40337

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