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Thalidomide Linker 1 (CAT#: PRLG-003)

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Specifications
Product Description Thalidomide linker 1 is thalidomide-PEG3-ethylamine. This synthesized compound incorporates a cereblon E3 ligase ligand and a PEG linker ready for conjugation to a target protein ligand.
Molecular Formula C23H30N4O9∙HCl
Molecular Weight (Da) 542.97
Chemical Name N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity 95%
Solubility 50 mg/mL in DMSO; 50 mg/mL in water
Size 10 mg
Physical State Lyophilized white powder
Storage Stored at -20 °C.
Target Information
Target Name Protein cereblon
Alternative Names CRBN; MRT2; MRT2A
Introduction Cereblon is the substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex. The complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Gene ID 51185
UniProt ID Q96SW2

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