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Datasheets
| Specifications | |
|---|---|
| Product Description | Apalutamide is a next-generation androgen receptor inhibitor that binds to the ligand-binding domain of AR, suppressing androgen-driven transcription. Its high affinity makes it an effective warhead for bifunctional chemical agents targeting AR. |
| Molecular Formula | C21H15F4N5O2S |
| Molecular Weight (Da) | 477.4 |
| Chemical Name | 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | AR |
| Alternative Names | AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM |
| Introduction | AR is a nuclear receptor transcription factor containing an N-terminal transactivation domain, a central DNA-binding domain with two zinc fingers, and a C-terminal ligand-binding domain. Upon androgen binding, it translocates to the nucleus and regulates target gene expression. |
| Gene ID | 367 |
| UniProt ID | P10275 |
| Related Disease | Prostate cancer, androgen insensitivity syndrome, spinal bulbar muscular atrophy |
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