ProDeg™ Atorvastatin, Target protein ligand (Protein Degrader) (CAT#: PRLG-015)
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Datasheets
| Specifications |
|---|
| Product Description |
Atorvastatin is a statin-class inhibitor of HMG-CoA reductase that binds to the catalytic domain of HMGCR, competitively blocking substrate access. It serves as a warhead for bifunctional chemical agents targeting HMGCR for proteasomal degradation. |
| Molecular Formula |
C33H35FN2O5 |
| Molecular Weight (Da) |
558.6 |
| Chemical Name |
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
HMGCR |
| Alternative Names |
LDLCQ3, LGMDR28, MYPLG |
| Introduction |
HMGCR (HMG-CoA reductase) is the rate-limiting enzyme of the mevalonate pathway, containing an N-terminal membrane-anchoring domain with eight transmembrane helices and a C-terminal catalytic domain. It catalyzes the conversion of HMG-CoA to mevalonate. |
| Gene ID |
3156 |
| UniProt ID |
P04035 |
| Related Disease |
Hypercholesterolemia, cardiovascular disease, hepatocellular carcinoma, prostate cancer |
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